Consistent with these findings, OPRK1 expression was lowest in AR+/NE− PCa lines (LNCaP, VCaP, 22RV1), intermediate in AR−/NE-like cells (PC3, DU145), and highest in bona fide NEPC cells (NCI-H660) (Supplementary Fig. 1F). The gene discussed is OPRK1; the disease is posterior cortical atrophy.