Furthermore, ROT is used as an animal model for Parkinsonism because it has been demonstrated in multiple studies to cause α-Synuclein aggregation and phosphorylation, oxidative stress, decreased feeding activities, impaired motor activities, decreased tyrosine hydroxylase (TH) expression, and dopamine secretion in addition to mitochondrial dysfunction [5–7]. The gene discussed is SNCA; the disease is Parkinson disease.