In an animal study conducted in male rats with metabolic syndrome (MetS) induced by feeding the animals for 8 weeks a concentrated fructose solution and high salt diet (delivered as food pellets), signs of BPH (prostate weight as well as histopathological indicators, such as interleukin 6 and the proliferation marker cyclin D1) significantly decreased when administering to the animals the CB1 antagonists AM 6545 or AM 4113 (10 mg/kg/day). This evidence concerns the gene CNR1 and benign prostatic hyperplasia.