The study further described the PD metagenome as indicative of a disease-promoting microbial profile, enriched with opportunistic pathogens and immunogenic components, dysregulated neuroactive signaling, an abundance of amyloidogenic molecules capable of inducing alpha-synuclein pathology, and overproduction of microbial toxins, accompanied by reduced resilience, characterized by a lower presence of anti-inflammatory and neuroprotective molecules [19]. This evidence concerns the gene SNCA and Parkinson disease.