The Extra Trees model prioritized tumor size, CA-125 and 28 proteins with known association with lung cancer (Fig. 7H), including Fascin-1 (FSCN1) (Chen et al, 2019), CD98hc (SCL3A2) (Li et al, 2023), Platelet-derived growth factor D (PDGF) (Donnem et al, 2008), CD16a (FCGR3A) (Wang et al, 2023), Hepcidin (HAMP) (Duru et al, 2012; Sonnweber et al, 2014), Azurocidin 1 (AZU1) and Collagen XV (COL15A1) (Liang et al, 2023), suggesting that our methodology successfully identified important proteins related to the disease phenotype. This evidence concerns the gene HAMP and neoplasm.