Overall, these results revealed that miR-96-5p-mediated phagocytosis of PDAC cells predominantly primes CD8+ T cells, and the linkage between innate (tumor cell phagocytosis due to CD47 inhibition by miR-96-5p overexpression) and adaptive immune responses (T-cell priming) is mediated by phagocytosis-induced antigen cross-presentation. The gene discussed is CD47; the disease is neoplasm.