The sole case with one primary tumor and two matched metastases had the three components sharing three somatic mutations, including a clonal ATRX missense mutation, a MEN1 frameshift mutation, and a DAXX missense mutation (both mutations deemed subclonal in the primary tumor and becoming fully clonal in the metastases; Fig. 4c, Supplementary Table S3). This evidence concerns the gene ATRX and neoplasm.