Interestingly, we showed that p53 isoforms (i.e., Δ40p53α or Δ133/Δ160p53) previously associated with cancers with more aggressive characteristics [23, 46, 47] tended (even if in a few cases not reaching the standard statistical significance) to be associated in UM samples with clinical parameters linked to a worse prognosis, such as tumor size, the increased risk of developing metastases, or the histological features (Fig. 4B–E). The gene discussed is TP53; the disease is cancer.