TP53 and neoplasm: Additionally, UM patients with a more severe cancer phenotype (i.e., larger cancer size, metastatic disease, and high-risk subtype) were associated with higher levels of the oncogenic p53 isoforms (namely Δ40p53α or Δ133/160p53α) or lower levels of p53 isoforms that are considered tumor-suppressive (i.e., p53β).