The UPMD1 cells showed a reduced p21 induction with respect to 92.1 cells (Fig. 2A); this could be due to the presence in this cell line of elevated levels of Δ160p53α (Fig. 2D), given that it is known that the expression balance among p53 isoforms with opposite functions (i.e., tumor suppressive vs. oncogenic, Fig. 6B, panel 3) has a relevant impact on the overall p53 transcriptional activity [23]. The gene discussed is TP53; the disease is neoplasm.