TP53 and cancer: While p53β and p53γ have been shown to support tumor suppression (i.e., senescence induction by p53β [24] and p53γ association with a better prognosis in breast cancer patients [25]), Δ133 and Δ160 p53 variants have been associated with cancer aggressiveness, by stimulating proliferation, angiogenesis, and migration in several cancers [24, 26, 27].