The ability of LA1011 to activate Hsp90, in a similar way to that seen for Aha1, is also a slight concern, since Aha1 is known to promote AD56, 57 and, in fact, Aha1 levels in the AD brain are induced above those of an age-related level.18, 19 However, it is important not to oversimplify the effects on specific co-chaperones of Hsp90 and the development of AD. Here, AQP1 is linked to Alzheimer disease.