79 With chronic hypervolemia, we observed a suppression of renin in control mice, whereas the renin levels of conditional knockouts displayed an insensitivity to the challenge (Figure 6C). Aldosterone levels trended toward suppression in control mice and were significantly lower in the conditional knockouts (Figure 6D). With chronic hypovolemia, we observed elevated renin and aldosterone in controls as expected (Figures 6E–F). The gene discussed is REN; the disease is Hypervolemia.