The p38/MK2 signaling axis regulates proinflammatorycytokine productionand RNA-binding protein activity in both immune cells and neurons.In microglia, this pathway drives the expression of TNF-α, IL-6,and other inflammatory mediators that contribute to Alzheimer’sdisease-associated neuroinflammation, synaptic dysfunction, and dendriticspine loss, ultimately impairing cognitive performance and plasticity. Inhibition of this axis reduces neuroinflammatorysignaling and improves memory in multiple AD models, highlightingits therapeutic relevance. The gene discussed is MAPK14; the disease is Alzheimer disease.