Therefore, our study aims to bridge this gap by systematically investigating the prognostic and functional relevance of critical mediators—TGFβ-1, IL19, CXCR4, BMP1, IL1A, VCAN, PDK1, and WNT2—in breast cancer progression and metastasis, and evaluating the potential of their targeted inhibition as a novel combinatorial therapeutic strategy. The gene discussed is PDK1; the disease is breast cancer.