SELP and neoplasm: NanoPROTACs were synthesized using an optimized nanoprecipitation protocol in which PROTACs dissolved in dimethyl sulfoxide (DMSO) were introduced via dropwise addition into an aqueous buffered solution containing the near-infrared (NIR) dye ICG, to stabilize the hydrophobic drug, and the polysaccharide fucoidan, to enable targeting to P-selectin within the tumor microenvironment (Fig. 1A).