CD4 and neoplasm: As shown in TIMER analysis (Fig 7A), the risk score was positively correlated with the infiltration of B cell (r = 0.29, p < 0.0001), T cell CD4 (r = 0.39, p < 0.0001), macrophages (r = 0.38, p < 0.0001), neutrophils (r = 0.48, p < 0.0001), and dendritic cells (r = 0.35, p < 0.0001), suggesting that patients in the high-risk group may exhibit an inflammatory and immunosuppressive tumor microenvironment.