In this study, we performed a comparative transcriptomics analysis between Major Depressive Disorder (MDD) acute neuroinflammation and AD chronic neuroinflammation to evaluate the role of Trem2-mediated Neurodegeneration-Related Modules (NEUD-MDL), often referred to as Disease-Associated Microglia (DAM), in anti-inflammatory microglial activation in AD. Here, TREM2 is linked to major depressive disorder.