TREM2 and Alzheimer disease: In addition, as the comparative transcriptomics and FACS-qPCR analysis showed, both the pro-inflammatory microglial subgroups (LPS-MDL and IFN-MDL) and the anti-inflammatory microglial subgroup (NEUD-MDL, Trem2-DAM) were significantly activated at the early stage of AD amyloid pathology.