The prognostic nutritional index (PNI), combining serum albumin and total lymphocyte count [11], is a well-established objective indicator of protein-energy wasting and malnutrition [12], providing valuable prognostic information in PD patients, often outperforming other nutritional indices like the Geriatric Nutritional Risk Index (GNRI) in simplicity and utility [13]. The gene discussed is ALB; the disease is nutritional deficiency disease.