IFNAR1 and systemic lupus erythematosus: Moreover, monoclonal antibody therapy targeting the IFN alpha receptor 1 (IFNAR1) elicited HSV-2 acute hepatitis in a patient with systemic lupus erythematosus (SLE) (Larsen et al., 2024), while AAN-I-IFNs were found in a patient with HSV-2 acute hepatitis (Martinot et al., 2023).