MFAP5 and systemic sclerosis: In the context of human pathology, MFAP5 is highly expressed in stromal fibroblasts of various human cancers, where it is associated with enhanced cancer fibrosis, angiogenesis, and chemoresistance, and in fibroblasts of fibrotic conditions such as idiopathic pulmonary fibrosis and systemic sclerosis [7, 8, 10, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25].