Although OVAII-specific CD4+ T cells were detected in draining LN (DLN) of Bpmel-OVAII tumor bearing mice (Fig. S1 D), only Bpmel-OVA but not Bpmel-OVAI or Bpmel-OVA-II exhibited an adjuvant effect, indicating that both MHC I and II epitopes were required for the cell adjuvant effect (Fig. 1 C). The gene discussed is CD4; the disease is neoplasm.