CD274 and neoplasm: Similarly, electrotransfection of pCAGGS-Notch2MUT into LLC tumor-bearing mice reversed anti–PD-L1 unresponsiveness (Fig. 8 D) and significantly promoted CD8+ TIL infiltration and 4-1BB expression on SLAMF6+ CD8+ TILs in LLC tumors (Fig. 8 E).