O-Linked N-acetylglucosamineprotein modification(O-GlcNAcylation) is a dynamic post-translational modification (PTM)in which a single N-acetylglucosamine moiety is attachedto serine or threonine residues of nuclear, cytoplasmic, and mitochondrialproteins.−,  This modification regulates diverse processes, includingtranscription, signaling, and protein localization,, and its dysregulationis associated with cancer, diabetes, cardiovascular disease, and neurodegenerativedisorders.,−, ,  Of note, O-GlcNAcylation is uniquely controlledby two enzymesO-GlcNAc transferase (OGT) and O-GlcNAcase (OGA). The gene discussed is OGA; the disease is cardiovascular disorder.