Additional approaches will be required to confirm the functional link between ANGPTL4 and IL1A in tumor initiation such as by assessing whether an IL1A blocking Ab phenocopies the effect of ANGPTL4 blocking Ab in the lung cancer model, and whether increased ANGPTL4 expression impacts the number of lesions, and if so its potential reversal using IL1A blocking antibody. The gene discussed is ANGPTL4; the disease is neoplasm.