NRG1 and cancer: To further characterize the neuroimmune transcriptional landscape during HCC progression, we analyzed the expression dynamics of nine neuroimmune‐associated genes that exhibited significant differential expression across cancer grades (G1xG2, G1xG3, G1xG4), along with synapse‐related genes, OLFM1 and NRG1, identified as differentially expressed between Grade 1 (G1) and Grade 4 (G4) tumors (Figure 7a).