Notably, EL219 at 30 mg/kg was well tolerated and outperformed LAMB at 5 mg/kg, a dose in mice that achieves exposures that are similar to or exceed the exposures achieved by the recommended dose of 3–5 mg/kg/day for treating patients with IPA (26, 27), even against isolates exhibiting resistance to conventional polyenes. This evidence concerns the gene GRAMD1B and Ito hypomelanosis.