GAS5 and cancer: In this study, the top three genes found to have the most significant fold change for upregulation and downregulation in AG12211 compared to HTB-172, were GAS5-AS1, ORLA2, and EIF4ALP5 genes that are oncogenic in various cancers, including lung cancer GAS5-AS1 has the greatest positive fold change in the data and is a long non-coding RNA established as an oncogene in lung and hepatocellular carcinoma [7].