Previous research has reported that Cel ameliorates mitochondrial function in obesity models via the AMPK/SIRT1 axis (Abu Bakar et al., 2020), and this work for the first time reveals a novel mechanism by which it regulates autophagy through the AMPK/ULK1 pathway in the context of AS. The gene discussed is SIRT1; the disease is obesity due to melanocortin 4 receptor deficiency.