Lysine-specific demethylase 1 (LSD1/KDM1A) scaffolds with GFI1/GFI1B and the CoREST complex to maintain a repressive transcriptional program that locks AML blasts in an immature state by limiting H3K4me1/H3K27ac accrual at myeloid enhancers, such as CEBPA- and PU.1-driven loci (Staehle et al., 2025). This evidence concerns the gene KDM1A and acute myeloid leukemia.