CXCR4 and Familial prostate cancer: For instance, downregulation of CXCR7 protein has been shown to increase migration in some settings, supporting a role for CXCR7 as a decoy receptor that sequesters CXCL12 and thereby counteracts CXCL12/CXCR4-mediated migration in prostate cancer (Yu et al., 2020).