CXCR2 and neoplasm: Notably, CXCR2 serves as a key receptor for multiple chemokines (e.g., CXCL1, CXCL2, CXCL8) and is critically involved in the recruitment of myeloid-derived suppressor cells (MDSCs), a potent population of immunosuppressive cells, into the tumor microenvironment (Liu et al., 2024).