In a myc-induced obesity-driven mouse model of prostate cancer, immunofluorescence staining of ventral prostate tissue shows high levels of CXCL12 in stromal compartments and high staining of CXCR4 and CXCR7 in tumor epithelial compartments (Saha et al., 2017). Here, ACKR3 is linked to Familial prostate cancer.