Additionally, Nocturnin expression is increased in dopamine neurons isolated from postmortem brains of PD patients (Simunovic et al., 2008) and increased in striatal spiny projection neurons following dopamine depletion and chronic L-DOPA treatment in models of dyskinesia (Charbonnier-Beaupel et al., 2015; Heiman et al., 2014). Here, NOCT is linked to Parkinson disease.