By preferred term, the most common nonserious AEs were increased insulin-like growth factor-I (IGF-I), above 2 SDS (59 events in 50 [17.2%] patients), headache (27 events in 27 [9.3%] patients), and arthralgia (14 events in 13 [4.5%] patients). This evidence concerns the gene IGF1 and Arthralgia.