YAP1 and neoplasm: This PI3K-mediated activation of downstream Hippo signaling is reciprocated by YAP which was found to inhibit translation of tumor suppressor, PTEN, through miR-29 and overexpression of YAP in transgenic mice was shown to have diminished PTEN expression in IHC staining (133). A systematic gain-of-function kinase screen identified PI3KCB to positively promote YAP/TAZ function in vitro (134). A combination of PI3KCB and TAZ coexpression also led to tumor formation in mice despite using nontumorigenic human mammary cell line MCF10A (134).