YAP1 and mesothelioma: For example, TEAD4 knockdown in HCT116, a colorectal cancer cell line, suppressed proliferation and tumor growth in BALB/c mice (82). A TEAD2 dominant negative construct was used to inhibit YAP activity in MSTO-211H cells, a mesothelioma line, by competing with endogenous TEAD leading to loss of proliferation in vitro, and tumor regression in vivo (83).