CMSP was observed to activate both intrinsic and extrinsic apoptotic pathways, suggesting that it may serve as an effective apoptosis inducer to inhibit OSCC progression.These findings are generally consistent with previous studies regarding the anticancer effects of natural organic compounds against oral cancer.Plumbagin, a naphthoquinone compound, has been shown to enhance its anticancer effects by arresting SCC25 cells at the G2/M phase through downregulation of CDK2 and Cyclin B1 expression (31). This evidence concerns the gene CCNB1 and lip and oral cavity carcinoma.