Reported toxicities included disease progression (n=5), gastrointestinal hemorrhage (n=1), death (n=1), pelvic infection (n=1), elevated blood uric acid (n=1), increased CRP (n=1), dehydration (n=1), back pain (n=1), flank pain (n=1), cauda equina syndrome (n=1), headache (n=1), and pneumonitis (n=1). This evidence concerns the gene CRP and pneumonitis.