PubMed was searched using a combination of Medical Subject Headings (MeSH) and free-text terms for sarcoma and Ewing sarcoma together with variations of IGF-1, IGF-1R, and relevant therapeutic agents (ganitumab, linsitinib, cixutumumab, robatumumab, figitumumab, dalotuzumab). This evidence concerns the gene IGF1R and Ewing sarcoma.