The KEGG signaling pathway involved the Proteasome, Renin-angiotensin system (RAS), prolactin signaling pathway, inflammatory bowel disease, growth hormone synthesis, secretion, and action (growth hormone synthesis, secretion and action, spinocerebellar ataxia, Th17 cell differentiation, neuroactive ligand-receptor interaction, and TNF signaling pathway. The gene discussed is TNF; the disease is cerebellar ataxia.