Though currently understudied, RPL26L1 contributes to the pathogenesis of systemic lupus erythematosus, polycystic ovary syndrome, endometrial cancer, vitiligo, and mantle cell lymphoma through key pathways including RIG-I-like receptor signaling, antigen processing/presentation, p53 signaling, mitochondrial translation, and ribosomal assembly (Afshin Derakhshani et al., 2020; Yang et al., 2020; Guo et al., 2020; Hassan et al., 2022). This evidence concerns the gene TP53 and systemic lupus erythematosus.