In MDD, CD74 interacts with MIF to promote depressive-like behaviors (Cristina Petralia et al., 2020), and our ssGSEA data showed CD74 correlates with Treg/γδ T cell infiltration-immune subsets specific to OSA (Treg elevation) and MDD (γδ T cell increase). This evidence concerns the gene CD74 and obstructive sleep apnea syndrome.