CASP8 and acute kidney injury: These coordinated transcriptional changes are spanning from receptors (Tnfrsf1b, Tnfrsf10b, Tnfrsf12a, Ltbr), initiator caspase (Casp8), adaptors (Pycard), downstream effectors (Pmaip1), to regulatory feedback nodes (Cflar, Tnfaip3, Bcl2l1, Mcl1) are consistent with activation of the death-receptor/caspase-8 axis upstream of the cleaved caspase-3 signal that resulted in exacerbated renal apoptosis and AKI in HFD + hIRI animals.