While most EV-studies in the context of T2D have been done on adipose tissue and macrophages (Deng et al., 2009; Kranendonk et al., 2014a; Kranendonk et al., 2014b; Ying et al., 2017), skeletal muscle is the primary site of glucose uptake in the body, and insulin resistance in this tissue is considered the primary defect in T2D pathogenesis (DeFronzo and Tripathy, 2009). The gene discussed is INS; the disease is type 2 diabetes mellitus.