On the other hand, the proteins with lower levels in the T2D group were related to neutrophil degranulation, post-translational protein phosphorylation, regulation of insulin-like growth factor (IGF) transport and uptake by IGFBPs, response to elevated platelet cytosolic Ca2+, and interconversion of nucleotide di- and triphosphates. The gene discussed is IGF1; the disease is type 2 diabetes mellitus.