Several recognized conditions associated with hyperopia: cortical cataract (index hyperopia), maternal smoking during gestation, aphakia (congenital or acquired), hyperglycemia, diabetes mellitus, and subsequent management of hyperglycemia in diabetes mellitus: 16p11.2 microdeletion, Myelin regulatory factor gene (MYRF) mutation, and familial predisposition to strabismus. The gene discussed is MYRF; the disease is congenital primary aphakia.