Antiphospholipid syndrome (APS) is an autoimmune disorder characterised by a persistent prothrombotic state caused by circulating antiphospholipid antibodies: lupus anticoagulant (LA), anticardiolipin (aCL), and anti‐β2‐glycoprotein I (anti‐β2GPI), in association with clinical evidence of vascular thrombosis or pregnancy morbidity [1]. The gene discussed is ACLY; the disease is autoimmune polyendocrinopathy.