In animal models of glaucoma, the pathways involved in RGC death include BAX/Caspase-dependent apoptosis 10-12, receptor interacting protein kinase 1/3 (RIPK1/3)/ mixed lineage kinase-like domain protein (MLKL)-dependent necroptosis 13, 14, and NOD-like receptor pyrin domain-containing protein 3 (NLRP3)/Caspase-1/Gasdermin D (GSDMD)-dependent pyroptosis 15, 16. The gene discussed is MLKL; the disease is glaucoma.