Notably, decreasing the expression and altering the activity of Piezo1 ion channels also increased the expression of Wnt7b in astrocytes (Figure 4D-F), suggesting the possibility of interconversion between Wnt7b- astrocytes and Wnt7b+ fibrotic astrocytes after ischemic stroke and that the Piezo1 ion channel in potentially involved in this process. The gene discussed is WNT7B; the disease is ischemic stroke.