HSP curtailed leukocyte infiltration into both the cerebral and spinal regions, while also altering the immune response by diminishing pro-inflammatory Th17 cells along with their associated cytokines (IL-17, IL-6), concurrently enhancing the presence of regulatory T cells (Tregs) and anti-inflammatory cytokines (IL-10, TGF-β). Here, IL6 is linked to hereditary spastic paraplegia.