A comprehensive investigation assessed the neuroprotective properties of HSP, a citrus-derived flavonoid, alongside DRB, an inhibitor of casein kinase 2 (CK2), within an in vitro model of AD utilizing differentiated SH-SY5Y neuronal cells subjected to amyloid-beta (Aβ1-42) exposure. Here, HSP90B2P is linked to Alzheimer disease.