Notably, HSP resulted in a significant attenuation of anxiety- and depression-associated behaviors, a reduction in pro-inflammatory cytokine levels (TNF-α, IFN-γ, IL-1β, IL-2, IL-6), and an augmentation of neurotrophic factors (NT-3, BDNF, NGF) within the striatum. The gene discussed is IFNG; the disease is Anxiety.