Unsupervised subtyping resolved five distinct fibroblast populations defined by unique marker gene signatures: inflammatory cancer-associated fibroblasts (iCAFs: high APOD, IGF1, ITM2A), matrix-producing cancer-associated fibroblasts (mCAFs: high MMP11, COL1A1, POSTN), antigen-presenting cancer-associated fibroblasts (apCAFs: high CD74, HLA-DPB1, HLA-DRA), pericytes (HIGD1B, FRZB, MT1A), and smooth muscle cells (SMCs: high CLSTN2, ADGRL3) (Supplementary Figures S1A-D). This evidence concerns the gene HIGD1B and cancer.