As a core component of the autophagy machinery, GABARAP facilitates autophagosome maturation and lysosomal fusion, positioning it as a central regulator of mitophagy with dual oncogenic implications: while promoting tumor suppression in certain contexts, its overexpression has been linked to radio-resistance in hepatocellular carcinoma and enhanced carcinogen-induced tumorigenesis (18, 19). The gene discussed is GABARAP; the disease is neoplasm.