AKT1 and neoplasm: The extracts also disrupt tumor-promoting signaling (e.g. AKT, STAT3, NF-κB, MAPK, VEGF/VEGFR) and metastasis-related factors (e.g. MMPs, E-cadherin) and can synergize with chemotherapies (cisplatin, doxorubicin, docetaxel) to enhance cancer cell killing (181, 182).