TP53 and malignant colon neoplasm: Bioactive compounds such as Trigonelline, Naringin, Kaempferol, Catechin, Quercetin, Embinin, Isorhamnetin, Apigenindin and Colchicine downregulated c-Myc and cyclin D1, suppressed beta-catenin signaling and caused p53-independent apoptosis (increased Bax/Bcl-2) in colon cancer (colon cancer stem cells, HCT116) (146).