Withaferin A and Withanone from ashwagandha leaves displayed anti-inflammatory, anticancer, apoptotic and cytotoxic effects by binding to and preventing the homodimerization of Survivin in several cancer cell lines, including Human normal lung fibroblasts (MRC-5, TIG-3, and WI-38) and a variety of cancer cells, including colon cancer (HCT116), breast cancer (MDA-MB-231, MCF-7 and T-47D), fibrosarcoma (HT1080), non-small lung cancer (A549), cervical cancer (HeLa, ME-180, SKG-II, and CaSki), osteosarcoma (U2OS and Saos-2), and melanoma (G361) (193). This evidence concerns the gene BIRC5 and melanoma.