Bioactive compounds such as Trigonelline, Naringin, Kaempferol, Catechin, Quercetin, Embinin, Isorhamnetin, Apigenindin and Colchicine downregulated c-Myc and cyclin D1, suppressed beta-catenin signaling and caused p53-independent apoptosis (increased Bax/Bcl-2) in colon cancer (colon cancer stem cells, HCT116) (146). This evidence concerns the gene CCND1 and colonic neoplasm.