A preclinical study of oral carcinoma cell lines, Ca9-22, HSC-2, HSC-3, HSC-4, demonstrated that Kaempferol and withanolide D kaempferol and withanolide D effectively inhibited oncogenic proteins, CDK2, and BRD3, inducing cytotoxicity via autophagy and caspase activation (196). Here, CDK2 is linked to lip and oral cavity carcinoma.