Extracts from the fruit increased ROS production, enhanced mitochondrial membrane potential, upregulated apoptotic genes (BAX, CASP3), modulated antioxidant (SOD2, GPX3) and inflammatory genes (IL6, IL-1 beta, TNF-alpha, TGF-beta) in chronic lymphoblastic leukemia (CLL) (149). Here, SOD2 is linked to B-cell chronic lymphocytic leukemia.