Ericifolin, gallic acid and eugenol derivatives have demonstrated anti-tumor, apoptotic, cytotoxic, chempreventive and anti-proliferative properties by increasing the levels of autophagy markers LC3B and LC3B-positive puncta and downregulating Akt and mTOR phosphorylation in breast cancer (triple negative breast cancer, TNBC – MDA-MB231 cells) (103). The gene discussed is AKT1; the disease is triple-negative breast carcinoma.