Curcumin modulates key oncogenic pathways such as RAS-ERK, PI3K/AKT/mTOR, COX-2, NF-κB, and JAK/STAT, showing efficacy in neurofibromatosis type 1, breast, cervical, lung, esophageal, uterine, prostate, pancreatic, hepatocellular, and colorectal cancers (111). This evidence concerns the gene NFKB1 and colorectal cancer.