However, in both non-diabetic and diabetic NOD mice expressing the dual Foxp3RFP/GFP reporter, we failed to detect evidence of selective Treg subset loss (Figure 2A), suggesting that the progression to overt diabetes may not be driven by acute pancreatic Foxp3+ Treg loss via in situ transdifferentiation, as observed in VAT. The gene discussed is FOXP3; the disease is diabetes mellitus.