MCMBP and neoplasm: Firstly, the analysis predominantly relies on sample data from public databases; although we observed low methylation and high m6A modification states of MCMBP in PAAD, further experimental validation is necessary to elucidate the precise mechanisms, such as how promoter hypomethylation enhances MCMBP transcription and how the associated m6A regulators affect its mRNA stability or translation, in driving tumor progression.