ADORA2B and gastric cancer: Protein stability regulation: Ser107 phosphorylation reduces Snail binding to E3 ubiquitin ligase β-TrCP by 72%, extending the protein half-life from 2.3 hours to 7.9 hours; Adora2b knockdown reverses this effect, reducing Snail expression by 47% (p<0.05) (29).Moreover, inhibition of extracellular adenosine production enhances anti-tumor immunity in preclinical GC studies (9, 30, 31), Specifically, Xu et al.