Promoting angiogenesis: Directly upregulates VEGF; HIF-1α/Adora2b amplifies VEGF effects via the HIF-1α/CREB complex (51, 53); clinically, their co-expression (68% of primary gastric cancers [59)] correlates with advanced TNM stage (p<0.01) and increased vascular density;. Here, CREB1 is linked to gastric cancer.