Treg expansion: Upregulates CTLA-4 via the same pathway [40% increase in CD80/CD86 binding affinity (10, 62, 63)]; Gastric cancer Adora2b+ cell clusters exhibit 2.1-fold higher CTLA-4 expression, correlated with poor prognosis [P<0.05 (9)];. The gene discussed is CTLA4; the disease is gastric cancer.