The interaction between integrins and the ECM not only mediates cell adhesion but also activates intracellular signaling pathways, including mitogen-activated protein kinase (MAPK) and phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT) pathways, regulating tumor cell proliferation, survival, migration, and invasion (95). The gene discussed is AKT1; the disease is neoplasm.