IFN-γ can promote the polarization of macrophages towards the M1 phenotype, enhancing their antitumor activity (104), and it can also upregulate the expression of major histocompatibility complex (MHC) class I molecules on the surface of tumor cells, improving the efficiency of antigen presentation and the recognition and killing of tumor cells by T cells (105). Here, IFNG is linked to neoplasm.