Briefly, CXCR1 and CXCR2 for instance, are predominantly associated with neutrophil recruitment and activation, yet they also participate in angiogenesis, epithelial regeneration, and tumor biology; CXCR3 is largely expressed on activated T cells and NK cells, where it mediates effector cell migration to inflamed tissues. This evidence concerns the gene CXCR3 and neoplasm.