CXCR3 has also been implicated in directing Tregs to sites of Th1-type inflammation through CXCL9, CXCL10, and CXCL11 (141), while CCR8 and its ligand CCL1 have been shown to mediate Treg accumulation in tumor microenvironments (142). Here, CXCR3 is linked to neoplasm.