In KIRC, R3HDM4 expression correlated significantly with clinicopathological characteristics, highlighting its potential role in tumor progression; tumor-infiltrating lymphocytes are strong indicators of tumor progression, histological differentiation, and nodal involvement, while complex crosstalk among malignant cells, stromal components, and immune populations in the tumor microenvironment contributes critically to pathogenesis. This evidence concerns the gene R3HDM4 and neoplasm.