1. Low concentration: Activates the nuclear factor-κB (NF-κB) pathway and induces EMT transformation of tumor cells;2. Maintains the M2-type pro-tumor phenotype of tumor-associated macrophages (TAMs);3. Upregulates the expression of PD-L1 in tumor cells and enhances immune escape ability;4. Activates proliferation signaling pathways such as MAPK/Akt to promote the survival of tumor cells. This evidence concerns the gene CD274 and neoplasm.