CASP8 and neoplasm: 1. High concentration: Destroys the structure of the tumor vascular bed, leading to ischemic necrosis of tumor tissue;2. Activates the anti-tumor functions of natural killer (NK) cells and cytotoxic T lymphocytes (CTLs);3. Induces apoptosis-related signaling pathways in tumor cells (e.g., activation of caspase-8)