For example, antibodies that target PD-1/PD-L1 obstruct the interaction between PD-1 and PD-L1, whereas antibodies against CTLA-4 impede the activity of CTLA-4, thereby enabling T cells to restore their functions and improve their capacity to identify and destroy cancer cells, leading to tumor management and eradication (59). This evidence concerns the gene CTLA4 and cancer.