1. In colorectal cancer: Activates the STAT1 pathway, recruits CD8+ T cells to the tumor microenvironment, and enhances their cytotoxicity;2. Activates the maturation of dendritic cells and promotes cross-presentation of antigens;3. Immunity-independent mechanism: Inhibits the clonal formation of tumor cells through autocrine signaling. The gene discussed is CD8A; the disease is neoplasm.